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In vivo induction of activin A-producing alveolar macrophages supports the progression of lung cell carcinoma.
Taniguchi S, Matsui T, Kimura K, Funaki S, Miyamoto Y, Uchida Y, Sudo T, Kikuta J, Hara T, Motooka D, Liu YC, Okuzaki D, Morii E, Emoto N, Shintani Y, Ishii M. Taniguchi S, et al. Nat Commun. 2023 Jan 17;14(1):143. doi: 10.1038/s41467-022-35701-8. Nat Commun. 2023. PMID: 36650150 Free PMC article.
Accordingly, follistatin, an antagonist of activin A is able to inhibit lung cancer cell proliferation. Single-cell RNA sequence analysis identifies a characteristic subset of AMs specifically induced in the tumor environment that are abundant in INHBA, and d …
Accordingly, follistatin, an antagonist of activin A is able to inhibit lung cancer cell proliferation. Single-cell RNA sequen …
Uncovering Tumor-Promoting Roles of Activin A in Pancreatic Ductal Adenocarcinoma.
Yu SY, Luan Y, Tang S, Abazarikia A, Dong R, Caffrey TC, Hollingsworth MA, Oupicky D, Kim SY. Yu SY, et al. Adv Sci (Weinh). 2023 Jun;10(16):e2207010. doi: 10.1002/advs.202207010. Epub 2023 Apr 21. Adv Sci (Weinh). 2023. PMID: 37083240 Free PMC article.
However, it still raises the question of whether activin A suppression renders favorable PDAC outcomes. Here, the authors demonstrate that activin A is abundantly detected in tumor and stromal cells on PDAC tissue microarray and mouse PDAC sections. .. …
However, it still raises the question of whether activin A suppression renders favorable PDAC outcomes. Here, the authors demo …
Activin A marks a novel progenitor cell population during fracture healing and reveals a therapeutic strategy.
Yao L, Lu J, Zhong L, Wei Y, Gui T, Wang L, Ahn J, Boerckel JD, Rux D, Mundy C, Qin L, Pacifici M. Yao L, et al. Elife. 2023 Dec 11;12:e89822. doi: 10.7554/eLife.89822. Elife. 2023. PMID: 38079220 Free PMC article.
Activin A directly stimulated myofibroblastic differentiation, chondrogenesis and osteogenesis in periosteal mesenchymal progenitor culture. Our data identify a distinct population of Activin A-expressing PPCs central to fracture healing and establish …
Activin A directly stimulated myofibroblastic differentiation, chondrogenesis and osteogenesis in periosteal mesenchymal proge …
Disrupting the TRIB3-SQSTM1 interaction reduces liver fibrosis by restoring autophagy and suppressing exosome-mediated HSC activation.
Zhang XW, Zhou JC, Peng D, Hua F, Li K, Yu JJ, Lv XX, Cui B, Liu SS, Yu JM, Wang F, Jin CC, Yang ZN, Zhao CX, Hou XY, Huang B, Hu ZW. Zhang XW, et al. Autophagy. 2020 May;16(5):782-796. doi: 10.1080/15548627.2019.1635383. Epub 2019 Jul 9. Autophagy. 2020. PMID: 31286822 Free PMC article.
The TRIB3-mediated autophagy impairment not only suppressed autophagic degradation of late endosomes but also promoted hepatocellular secretion of INHBA/Activin A-enriched exosomes which caused migration, proliferation and activation of hepatic stellate cells …
The TRIB3-mediated autophagy impairment not only suppressed autophagic degradation of late endosomes but also promoted hepatocellular secret …
Activin A is anti-lymphangiogenic in a melanoma mouse model.
Heinz M, Niederleithner HL, Puujalka E, Soler-Cardona A, Grusch M, Pehamberger H, Loewe R, Petzelbauer P. Heinz M, et al. J Invest Dermatol. 2015 Jan;135(1):212-221. doi: 10.1038/jid.2014.328. Epub 2014 Aug 1. J Invest Dermatol. 2015. PMID: 25084052 Free article.
Activin A is known to reduce blood vessel formation, but the effects on lymphangiogenesis are unknown. ...Using our mouse model with melanoma cells overexpressing Wnt1, FST, Wnt1/FST, or the inhibin betaA subunit (INHBA, resulting in activin A e …
Activin A is known to reduce blood vessel formation, but the effects on lymphangiogenesis are unknown. ...Using our mouse mode …
Activin A and CCR2 regulate macrophage function in testicular fibrosis caused by experimental autoimmune orchitis.
Peng W, Kepsch A, Kracht TO, Hasan H, Wijayarathna R, Wahle E, Pleuger C, Bhushan S, Günther S, Kauerhof AC, Planinić A, Fietz D, Schuppe HC, Wygrecka M, Loveland KL, Ježek D, Meinhardt A, Hedger MP, Fijak M. Peng W, et al. Cell Mol Life Sci. 2022 Nov 24;79(12):602. doi: 10.1007/s00018-022-04632-4. Cell Mol Life Sci. 2022. PMID: 36434305 Free PMC article.
Taken together, our data indicate that CCR2 and activin A promote fibrosis during testicular inflammation by regulating macrophage function. Inhibition of CCR2 or activin A protects against damage progression, offering a promising avenue for therapeuti …
Taken together, our data indicate that CCR2 and activin A promote fibrosis during testicular inflammation by regulating macrop …
Circulating Activin A, Kidney Fibrosis, and Adverse Events.
Tsai MT, Ou SM, Lee KH, Lin CC, Li SY. Tsai MT, et al. Clin J Am Soc Nephrol. 2023 Nov 20;19(2):169-77. doi: 10.2215/CJN.0000000000000365. Online ahead of print. Clin J Am Soc Nephrol. 2023. PMID: 37983094
We performed RNA sequencing and histological analyses on kidney biopsy specimens to assess activin A expression. In vitro experiments were also conducted to explore the potential attenuation of TGF- beta -induced fibroblast activation through activin A …
We performed RNA sequencing and histological analyses on kidney biopsy specimens to assess activin A expression. In vitro expe …
Activin A does not drive post-traumatic heterotopic ossification.
Hwang C, Pagani CA, Das N, Marini S, Huber AK, Xie L, Jimenez J, Brydges S, Lim WK, Nannuru KC, Murphy AJ, Economides AN, Hatsell SJ, Levi B. Hwang C, et al. Bone. 2020 Sep;138:115473. doi: 10.1016/j.bone.2020.115473. Epub 2020 Jun 15. Bone. 2020. PMID: 32553795
In order to explore the role of activin A in tHO, we performed single cell RNA sequencing and compared the expression of activin A as well as other BMP pathway genes in tHO and FOP HO. ...Given that wild type ACVR1 does not transduce signal when engage …
In order to explore the role of activin A in tHO, we performed single cell RNA sequencing and compared the expression of ac …
Blockade of Activin Receptor IIB Protects Arthritis Pathogenesis by Non-Amplification of Activin A-ACVR2B-NOX4 Axis Pathway.
Jeon J, Lee H, Jeon MS, Kim SJ, Choi C, Kim KW, Yang DJ, Lee S, Bae YS, Choi WI, Jung J, Eyun SI, Yang S. Jeon J, et al. Adv Sci (Weinh). 2023 May;10(14):e2205161. doi: 10.1002/advs.202205161. Epub 2023 Mar 22. Adv Sci (Weinh). 2023. PMID: 36950748 Free PMC article.
Activin A Tg mice (Col2a1-Inhba) exhibit enhanced cartilage destruction, whereas heterozygous activin A KO mice (Inhba(+/-) ) show protection from cartilage destruction. ...Activin A Tg:Nox4 KO (Col2a1-Inhba:Nox4(-/-) …
Activin A Tg mice (Col2a1-Inhba) exhibit enhanced cartilage destruction, whereas heterozygous activin A K …
Mechanisms of myostatin and activin A accumulation in chronic kidney disease.
Bataille S, Dou L, Bartoli M, Sallée M, Aniort J, Ferkak B, Chermiti R, McKay N, Da Silva N, Burtey S, Poitevin S. Bataille S, et al. Nephrol Dial Transplant. 2022 Jun 23;37(7):1249-1260. doi: 10.1093/ndt/gfac136. Nephrol Dial Transplant. 2022. PMID: 35333341
In mice with CKD, myostatin and activin A blood concentrations were increased. Mstn was not upregulated in CKD mice tissues. ...We propose to add myostatin and activin A to the list of uremic toxins....
In mice with CKD, myostatin and activin A blood concentrations were increased. Mstn was not upregulated in CKD mice tissues. . …
89 results